p cdk6 (Proteintech)
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96
Structured Review
Proteintech
p cdk6
P Cdk6, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 314 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/p+cdk6/CDK6+Antibody/pm41785828-53-24-31
Average 96 stars, based on 314 article reviews
P Cdk6, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 314 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/p+cdk6/CDK6+Antibody/pm41785828-53-24-31
Average 96 stars, based on 314 article reviews
p cdk6 - by Bioz Stars,
2026-11
96/100 stars
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other:Article Title: Light-activated targeted degradation of VHL drug for selective tumor killing: A novel strategy for precision therapy of bladder cancer. Article Snippet: Photodegradation-targeting chimeras (PDTACs) addresses the off-target toxicity issues of proteolysis-targeting chimeras (PROTACs) in terms of technical principle; Difficulty in defining tumor boundaries and controlling light exposure increases the risk of damaging peritumoral tissues if light exposure oversteps the tumor.. This study discovered that compared to SV-HUC-1 cells (normal cells), Von Hippel-Lindau (VHL) exhibits more active regulation of CDK2/4 in T24 cells (bladder cancer cells); Based on this, a series of PDTACs linking VHL ligands to photosensitizers were synthesized, and ZnPc-PEG2-VH032 was selected as the most potent antitumor compound.. This compound degrades VHL upon light exposure and, when combined with photodynamic therapy (PDT), efficiently kills T24 cells with a phototoxicity index (PI) of 36,397. |